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KMID : 0361019980410010073
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Korean Journal of Otolaryngology - Head and Neck Surgery
1998 Volume.41 No. 1 p.73 ~ p.76
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Detection of Epstein-Barr Virus DNA in Oropharynx by Polymerase Chain Reaction
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도남용/Nam Yong Doh
김완수/김성현/이준한/이도용/최봉남/Wan Soo Kim/Sung Hyun Kim/Jun Han Lee/Do Yong Lee/Bong Nam Choi
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Abstract
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Background and Objectives: The Epstein-Barr virus (EBV) is a human herpes virus which causes infectious mononucleosis and is associated with such human cancers as Burkitt's Lymphoma, Hodgkin's disease, non-Hodgkin's disease, and
nasopharyngeal
carcinoma. However, the role of EBV as a causative factor in other head & neck tumors is not fully elucidated. This study analyzed the detection rate of Epstein-Barr virus (EBV) in the throat washing samples from pateints with head and neck
tumors
and
non-malignant diseases, as well as from normal subjects. Matherials & Methods: The throat washing samples were collected from 49 patients of head & neck tumors, 52 patients of non-malignant diseases (pharyngitis and tonsillitis) and 24
normal
subjects. The EBV DNA was detected in 25 (51%) of the 49 throat washing samples from patients with tumors, as well as 3 (60%) of 5 samples from patients with nasopharyngeal carcinoma, and 22 (50%) of 44 samples from patients with head and neck
tumors.
The throat wasing samples from 52 patients with non-malignant diseases and 24 samples from healthy subjects were also examined. EBV was detected in 17 (32.7%) of 52 patients with non-malignant diseases and 3 (12.5%) of 24 samples from healthy
subjects.
Conclusion: These data indicate that the EBV may be related to non-malignant diseases and head and neck tumor.
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KEYWORD
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